College of Health and Human Services
George Mason University
George Mason University Mason
George Mason University

Germaine Louis, PhD, MS

Dean, College of Health and Human Services

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Biography

Dr. Germaine M. Buck Louis is an internationally recognized reproductive and perinatal epidemiologist whose expertise focuses on environmental influences on human fecundity and fertility.  Her research has focused on a mixture of environmental exposures, including endocrine disrupting chemicals, stress and lifestyle in relation to a spectrum of reproductive outcomes in both men and women.  In addition, Dr. Buck Louis’ research continues to focus on the implications of fecundity and fertility for health across the lifespan.  A complimentary and parallel avenue of research includes methods aimed at addressing challenges, such as the complexity associated with studying environmental mixtures and the clustering of reproductive outcomes.  She is an early pioneer in the application of the exposome research paradigm for understanding environmental influences on human fecundity and fertility impairments.  During her career, she has served as Principal Investigator for original extramural and intramural research totally over $53 million.

Prior to becoming the Dean of the College of Health and Human Services in October 2017, Dr. Buck Louis was the Director for the Division of Intramural Population Health Research at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health.  This position was preceded by her role as a tenured professor in the Department of Social and Preventive Medicine, University of Buffalo, School of Medicine and Biomedical Sciences, where she taught in both the graduate and medical schools.  She has published numerous scientific papers and technical reports, and co-edited the textbook Reproductive and Perinatal Epidemiology.  She has provided considerable service to The National Academies, Pan American Health Organization, U.S. Environmental Protection Agency, and World Health Organization among other governmental agencies.  She has been the President of the Society for Pediatric and Perinatal Epidemiologic Research, President of the Society for Epidemiologic Research and Councilor for the International Society for Environmental Epidemiology.  Currently, Dr. Buck Louis serves on the Board for the American College of Epidemiology and the Board on Environmental Studies and Toxicology (BEST), National Academies of Sciences, Engineering and Medicine.  Dr. Buck Louis is the recipient of many awards for research excellence, mentoring and service. 

Degrees

PhD, Epidemiology, State University of New York at Buffalo

MS, Epidemiology, State University of New York at Buffalo

Personal Websites:

Research

Research Interests

  • Human reproduction and development
  • Environmental influences on human fecundity and fertility
  • Endocrine disruptors
  • Exposome
  • Research methods

Refereed Publications 2019

Choi G, Wang Y-B, Sundaram R, Chen Z, Barr DB, Buck Louis GM, Smarr MM. Polybrominated diphenyl ethers and incident pregnancy loss:  The LIFE Study. Environmental Research. 2019;168:375-381. PMID: 30384231 

Zhang W, Chen Z, Liu A, Buck Louis GM. A weighted kernel machine regression approach to environmental pollutants and infertility. Statistics and Medicine 2019;38:809-827. PMID: 30328128

Wang Yu-Bo, Chen Z, Goldstein JM, Buck Louis GM, Gilman, SE. A Bayesian regularized mediation analysis with multiple exposures. Statistics in Medicine 2019;38:828-843. PMID: 30375022

Chung MK, Buck Louis GM, Kannan K, Patel CJ. Exposome-wide association study of semen quality: systematic discovery of endocrine disrupting chemical biomarkers in fertility require large sample sizes. Environment International 2019;125:505-514. PMID: 30583854 

Hemmert R, Schliep KC, Willis S, Peterson CM, Buck Louis GM, Allen-Brady K, Simonsen S, Stanford J, Willis S, Byun J, Smith K. Modifiable lifestyle factors and risk for incident endometriosis. Paediatric and Perinatal Epidemiology 2019;33:19-25. PMID: 30307628 

Rahman M, Zhang C, Smarr MM, Lee S, Honda M, Kannan K, Ayele-Tekola F, Buck Louis GM. Persistent organic pollutants and gestational diabetes: A multi-center prospective cohort study of healthy US women. Environment International 2019;124:249-258. PMID: 30660025

Owens J, Albert PS, Buck Louis GM, Fuchs KM, Grobman WA, Kim S, D’Alton ME, Wapner R, Wing DA, Grantz KL.   A contemporary amniotic fluid volume standard for the United States: the NICHD Fetal Growth Studies – Singletons. American Journal of Obstetrics & Gynecology. 2019;21(1);e1-67. PMID: 30790566

Mills JL, Mehnaz A, Buck Louis GM, Kannan K, Weck J, Wan Y, Maisog J, Giannakou A, Sundaram R. Pregnancy loss and iodine status: The LIFE Prospective Cohort Study. Nutrients 2019;11:534. PMID: 30823683 

Smarr MM, Bible J, Gerlanc N, Buck Louis GM, Bever A, Grantz KL. Comparison of fetal growth by maternal prenatal acetaminophen use. Pediatric Research. 2019 Aug;86(2):261-268. PMID: 30911064 

Hwang BS, Chen Z, Buck Louis GM, Albert P. A Bayesian multi-dimensional couple-based latent risk model with an application to infertility. Biometrics. 2019;75(1)315-325. PMID: 26295923

Grewal J, Buck Louis GM, Hinkle S, Mumford SL, Lu Y-L, Nansel TR, Perkins N, Mills J, Liu A, Schisterman EF.  Advancing the health of populations across the life course: 50 years of discoveries in the Division of Intramural Population Health Research. Epidemiology. 2019;30, Suppl 2:S47-S54. PMID: 31569152 

Kahn LG, Widen EM, Janevic T, Straka N, Liu X, Cirillo PM, Cohn BA, Buck Louis GM, Factor-Litvak P. The relation of birth weight and adiposity across the life course to semen quality in middle age. Epidemiology. 2019;20, Suppl 2:S17-S27. PMID: 31569149 

Yeung E, Bell E, Sundaram R, Ghassabian A, Ma W, Kannan K, Buck Louis GM. Examining endocrine disruptors measured in newborn dried blood spots and early childhood growth in a prospective cohort.  Obesity. 2019;27(1):145-152. PMID: 3056934 

Bell GA, Perkins N, Buck Louis GM, Kannan K, Bell EM, Yeung EH. Exposure to persistent organic pollutants and birth weight: The Upstate KIDS Study. Epidemiology. 2019;30, Suppl 2:S94-S100. PMID: 31569158 

Buck Louis GM, Yeung E, Kannan K, Maisog J, Zhang C, Grantz K, Sundaram R. Patterns and variability of endocrine disrupting chemicals during pregnancy: Implications for understanding the exposome of normal pregnancy. Epidemiology. 2019;30 (suppl 2):S65-S75. PMID: 31569155

Zheng Y, Zhang C, Weisskopf M, Williams PL, Parsons PJ, Palmer CD, Buck Louis GM, James-Todd T. Early pregnancy metal(loid)s concentrations and gestational glucose levels. Journal of Clinical Endocrinology and Medicine. 2019;104(10):4295-4303. PMID: 31095302

Amyx MM, Albert PS, Bever AM, Hinkle SN, Owen J, Grobman WA, Newman RB, Chien EK, Gore-Langton RE, Buck Louis GM, Grantz KL.  Associations between estimated foetal weight discordance and clinical characteristics within dichorionic twins.  The NICHD Fetal Growth Studies.  Paediatric and Perinatal Epidemiology. 2019;33(5):332-342. PMID: 3147822700.

Amyx MM, Albert PS, Bever AM, Hinkle SN, Owen J, Grobman WA, Newman RB, Chien EK, Gore-Langton RE, Buck Louis GM, Grantz KL. Intrauterine growth discordance in dichorionic twins. American Journal of Obstetrics and Gynecology, 2019; Aug 24. doi:10.1016/j.ajog.2019.08.02. PMID: 31454510

Tekola-Ayele F, Workalemahu T, Gorfu G, Shrestha D, Tycko B, Wapner R, Zhang C, Buck Louis GM. Sex differences in the associations of placental epigenetic aging with fetal growth. Aging. 2019; 11(15):5412-5432. PMID: 31395791

Ouidir M, Buck Louis GM, Kanner J, Grantz KL, Zhang C, Sundaram R, Rahman ML, Lee S, Kannan K, Tekola-Ayele F, Mendola P. Persistent organic pollutant exposure during early pregnancy and longitudinal fetal growth in the NICHD Fetal Growth Studies - Singletons. JAMA Ped. In Press. 

Levine LD, Kim K, Purdue-Smithe A, Sundaram R, Schisterman EF, Connell M, DeVilbiss E, Alkhalaf Z, Radoc J, Buck Louis GM, Mumford SL. Urinary phytoestrogens and menstrual cycle length and variability among healthy eumenorrheic women. Journal of the Endocrine Society. In Press.

Kim S, Chen Z, Perkins NJ, Schisterman EF, Buck Louis GM. A model-based approach to detection limits in studying environmental exposures and human fecundity. Statistics in Biosciences. June 7, 2019. DOI 10.1007/S12561-019-09232-5. In Press.

Honors & Awards

NICHD Collaboration Award, 2017, Eunice Kennedy Shriver National Institute of Child Health & Human Development

Society for Pediatric & Perinatal Research President’s Inaugural Award, 2014, Society for Pediatric & Perinatal Research

NIH Mentoring Award, 2004, National Institutes of Health

Service Award, 2000, International Society for Environmental Epidemiology

Abraham Lilienfeld Award, 1987, Society for Epidemiologic Research

Expertise